Abstract
We consider the delay differential equations \(P'(t) = \frac{{\beta _0 \theta ^n [P(t - \tau )]^j }}{{\theta ^n + [P(t - \tau )]^n }} - \delta P(t),{\rm{ }}j = 0,1,\) which were proposed by Mackey and Glass as a model of blood cell production. We suggest new conditions sufficient for the positive equilibrium of the equation considered to be a global attractor. In contrast to the Lasota-Wazewska model, we establish the existence of the number δj = δj(n, τ) > 0 such that the equilibrium of the equation under consideration is a global attractor for all δ ε (0, δj] independently of β0 and θ.
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References
M. C. Mackey and L. Glass, “Oscillation and chaos in physiological control systems,” Science, 197, 287–289 (1977).
K. Gopalsamy, M. R. S. Kulenovich, and G. Ladas, “Oscillations and global attractivity in models of hematopoiesis,” J. Dynam. Different. Equat., 2, No. 2, 117–132 (1990).
A. F. Ivanov and A. N. Sharkovsky, “Oscillations in singularly perturbed delay equations,” Dvnam. Rep., 1, 164–224 (1991).
G. Karakostas, Ch. G. Philos, and Y. G. Sficas, “Stable steady state of some population models,” J Dynam. Different. Equat., 4, No. 1. 161–190 (1989).
J. Mallet-Paret and R. D. Nussbaum, “Global continuation and asymptotic behaviour for periodic solutions of differential delay equations,” Ann. Mat. Pura Appl, 145, 33–128 (1986).
I. Györi and G. Ladas, Oscillations Theory of Delay Differential Equations with Applications, Oxford University Press, London (1991).
K. Gopalsamy, “Stability and oscillations in delay differential equations of population dynamics,” Math. Appl., 74, 501 (1992).
A. F. Ivanov, “On global stability in nonlinear discrete models,” Nonlinear Anal., 23, No 11, 1383–1389 (1994).
G. Karakostas, Ch. G. Philos, and Y. G. Sficas, “Stable steady state of some population models,” J Dynam. Different. Equat., 17, No. 11. 161–190 (1992).
M. Wazewska-Czyzewska and A. Lasota, “Mathematical problems of the red-blood cell system.” Ann. Pol. Math. Soc., Ser. III. Appl. Math., 6, 23–40 (1976).
I. Györi and S. Trofimchuk, Global Attractivity in x’ (t) = -δx(t) + pf(x(t-τ)), Preprint No. 057, University of Veszprem, Veszprem (1996).
J. K. Hale, Theory of Functional-Differential Equations. Springer, Berlin (1977).
D. Singer, “Stable orbits and bifurcation of maps of the interval,” SIAM J. Appl. Math., 35, No. 2, 260–267 (1978).
A. N. Sharkovskii, S. F. Kolyada, A. G. Sivak, and V. V. Fedorenko, Dynamics of One-Dimensional Dynamical Systems [in Russian], Naukova Dumka, Kiev (1989).
J. K. Hale, “Asymptotic behavior of dissipative systems,” in: Mathematical Surveys and Monographs, No. 25, Am. Math. Soc., Providence (1988).
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Published in Ukrainskii Matematicheskii Zhurnal, Vol. 50, No. 1, pp. 5–12, January, 1998.
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Gopalsamy, K., Trofimchuk, S.I. & Bantsur, N.R. A note on global attractivity in models of hematopoiesis. Ukr Math J 50, 3–12 (1998). https://doi.org/10.1007/BF02514684
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DOI: https://doi.org/10.1007/BF02514684